R & D capabilities

Biomedical Signal Processing and Analysis

Biomedical signals are recorded and analyzed in order to gather information about the state of health of the patient or to study the activity of an organ. Sometimes these signals analysis methodology is well documented and is almost a standard such as the determination of the heartbeat of the electrocardiogram. However if more information than the usual is needed or the signal under study is unconventional, new techniques for the characterization of the signals or for the elimination of possible interferences are necessary. 

Our research group has made special emphasis in the signal processing of bioelectric signals captured on the body surface as those of intestinal, uterine and cardiac origin. From the latter heart rate variability parameters have been derived that provide information on the operation of the sympathetic and parasympathetic nervous system. We have also developed techniques for the elimination of interferences such as breathing, baseline drifts, movement artefacts or cardiac interferences. Moreover, it has been defined and obtained parameters that allow characterizing the activity of the organ under study. 
The implementation of the proposed techniques has allowed improving the quality of the recorded signals and getting more robust characteristic parameters. 

These results are being employed by various international research groups, as well as clinical staff at various hospitals. In addition these techniques have been the subject of various publications in prestigious international journals.

Key People:

  • Garcia Casado, Francisco Javier 
  • Martínez De Juan, José Luís
  • Prats Boluda, Gema
  • Ye, Yiyao 

Responsable:

  • Garcia Casado, Francisco Javier 

Information about technology:

  • Applications Monitoring and characterization of the activity of organs such as the heart, brain, intestine, stomach, uterus, etc.
    Systems to help clinical diagnosis.
    Studies of the physiology of organs.
    Embedded software in biomedical devices.
  • Benefits that it provides Improvement in the quality of weak signals and low signal-to-noise ratio, signal-interference.
    Increase in the robustness of characteristic parameters of biomedical signals.
    Obtaining additional and covert information in biomedical signals.
  • Technical advantages Versatility and robustness in biosignal monitoring systems and diagnostic aid.
    Added value in biomedical devices.

Advice and translation of patents

The translation of patents is a specialized translation modality that, in addition to the specialized content, has its own conventions of format that must be fulfilled in order to be able to apply for the patent in the target market with rigor and reliability. The existence of translation errors can have serious consequences in the act of registering or using the patent. Therefore, the correct selection of technical terms is crucial to translate a patent clearly into another language.

In this sense, the translation into Spanish of patents for inventions related to Biomedical Engineering is especially delicate because it is an emerging field for which there is no specific corpus. The English-Spanish translation of this type of patent requires, more than in any other field, a deep knowledge of the field of Biomedical Engineering both from the scientific point of view and from the technical point of view.

The Center for Research and Innovation in Bioengineering (Ci2B) of the Polytechnic University of Valencia is one of the pioneer centers in Spain in Biomedical Engineering, both at the teaching and research level. In addition to its activity in research and development of software and hardware for biomedical applications, the center was chosen in 2010 to collaborate with the prestigious intellectual property company ELZABURU, SLP to carry out advice on the translation of biomedical engineering patents ( and, by extension, other related fields of engineering). The accumulated experience of recent years has been translated into more than 100 translations of patents from English into Spanish and at the beginning of the elaboration of a specific corpus of Biomedical Engineering that complements already existing corpora, such as Patentscope or COPPA (Corpus of Parallel Patent Applications) and that complies with standard EN 15038.

Recently, the newly created company VAELIZA TRANSLATIONS, AEIE, associated with ELZABURU, SLP, has shown interest in collaborating with the Center for Research and Innovation in Bioengineering for the same purpose.

In addition to the translation of specific patents of Biomedical Engineering itself and the gradual generation of the aforementioned corpus, the collaboration provided by the Ci2B of the UPV has potential applications in the automated translation of patents.

Key People:

  • Ferrero De Loma-Osorio, José María  

Responsable:

  • Ferrero De Loma-Osorio, José María  

Information about technology:

  • Applications Patent translation and linguistic advice
  • Benefits it brings - Terminology adaptation
    - Linguistic correction
  • Technical advantages Preparation of a specific corpus of Biomedical Engineering

Help in the diagnosis of hemophilic arthropathy

Hemophilic arthropathy is an articular destruction associated with hemophilia. The most affected joints are the knees, ankles, elbows, hips and shoulders.
Researchers at CI2B have a system that helps in the diagnosis of hemophilic arthropathy with a high success rate (> 95%), based on a non-invasive measure, low cost and independent of the observer.
Compared to other systems that aid in the diagnosis of hemophilic arthropathy, such as those based on biomedical images, the system does not subject the patient to any type of radiation or ultrasonic waves. Furthermore, the result is not subject to interobserver variability. It is also not subject to questions related to the interpretation of the patient's symptoms.
The tests and their results can be obtained in less than 15 minutes, all with a system whose associated cost can be significantly lower than other employees in the clinical sector at present.

Key People:

  • Garcia Casado, Francisco Javier, 
  • Prats Boluda, Gema 
  • Ye, Yiyao  

Responsable:

  • Garcia Casado, Francisco Javier 

Information about technology:

  • Applications The main application of the acquired knowledge and associated technology is the help in the diagnosis of hemophilic arthropathy.
    However, its use could also be extended to the detection of arthropathies due to other causes, as well as to the study of other types of disorders that affect the proprioception of people and may alter their balance.
  • Benefits that it provides A system has been developed that allows the diagnosis of hemophilic arthropathy with a high success rate (> 95%), based on a non-invasive measure, low cost and independent of the observer.
  • Technical advantages In contrast to other systems to aid in the diagnosis of hemophilic arthropathy, such as those based on biomedical images, the proposed system does not subject the patient to any type of radiation or ultrasonic waves. Furthermore, the result is not subject to interobserver variability. It is also not subject to questions related to the interpretation of the patient's symptoms.
    The tests and their results can be obtained in less than 15 minutes, all with a system whose associated cost may be significantly lower than other employees in the clinical sector at present.

Development of piezoelectric "label free" biosensors "High resolution QCM" for prevention and diagnosis in Health

Currently, in the fields of medical diagnosis and biotechnology there is an increasingly growing demand for analytical techniques that allow rapid, easy, direct and real-time detection of pathogens such as bacteria and viruses, characterizing protein absorption and DNA interactions. and RNA with complementary sequences or analyze the antigen-antibody reactions, among other applications.

In the past, "label free" biosensors have been mainly used in the pharmaceutical industry, with the main drawback being their high costs and the need for expert users to handle and interpret the data. However, the new challenges faced by research means that companies and R & D centers are demanding more sensitive label free biosensors with the capacity to analyze in real time, at a reduced cost and easy to use and interpret. information

In this field, CI2B researchers are working on the development of new piezoelectric biosensors, based on the use of quartz crystal microbalances (QCM). The microgravimetric technique has allowed the implementation of a quantitative, direct and real-time detection method of biomolecular interactions such as antigen-antibody, pathogen detection, cell adhesion, oligonucleotide adsorption and hybridization, and complementary DNA sequence interactions, characterization of the absorption of proteins, and detection of bacteria and viruses, among others.

The main advantages of the "label free" biosensors are simple, direct, and real-time detection, as well as their regeneration capacity, which offers important advantages in relation to conventional analysis techniques. Thus, for example, a developed piezoelectric biosensor is capable of detecting the target antigen in a small fluid sample in less than 15 minutes and regenerating the sensor up to 150 times in a cyclic process, without significant loss of sensitivity.

Recently this team has made important advances both in the characterization techniques and in the sensor support technology and the associated fluidics, which may allow tackling the pending challenges for their application to the development of biochemical sensors, and in particular of piezoelectric biosensors " label free ".

The group led by Professor Antonio Arnau has recently managed to develop a new generation of quartz microbalance sensors of very high frequency, with sensitivities far superior to those currently available, which will allow to increase more than 1000 times (3 orders of magnitude) the limit of detection of these sensors in relation to conventional microbalances, reaching, and even exceeding, the limits of the current "label free" optical systems. All this, together with the advances of the group in the characterization techniques of these sensors, has provided the basis for a new generation of microbalances called "High Resolution QCM".

Professor Arnau with other members has created a company, spin-off of the Universitat Politècnica de València, called "Advanced Wave Sensors (AWSensors)" in order to transfer the results of both years of research.

Key People:

  • Arnau Vives, Antonio  

Responsable:

  • Arnau Vives, Antonio  

Information about technology:

  • Applications Detection of biomolecular interactions (antigen-antibody, detection of pathogens, cell adhesion, adsorption and hybridization of oligonucleotides and interactions of complementary sequences of DNA, characterization of protein absorption, and detection of bacteria and viruses, among others)
  • Benefits provided by rapid, easy, direct and real-time detection of biomolecular interactions
  • Technical advantages

Study and Characterization of Gastrointestinal Activity

The stomach and intestines are organs of difficult access and monitoring non invasively their activity in vivo subjects is limited. Currently the most widespread technique for its monitoring is the use of pressure sensors which should be introduced to the extent desired via nasal or oral. This technique is difficult for the clinician, annoying for the patient and presents various technical as well as physiological problems.

Our research group has developed an alternative non-invasive method of based on acquiring the myoelectrical activity of such organs through electrodes placed on the abdominal area. The acquired signal is very weak in amplitude and is subject to various physiological interferences, therefore special techniques of signal conditioning and processing are needed for its correct characterization. The results of our studies have demonstrated the possibility of capturing, in animal model, the intestinal pacemaker activity (slow wave) and the spike bursts whose activity is directly correlated with intestinal contractile activity. Further studies in humans confirm the possibility of detecting the intestinal slow wave on the body surface which could allow non-invasive diagnosis of pathologies such as intestinal ischemia or disorders associated with thyroid disorders or hypokalemia.

These studies have been carried out in collaboration with expert clinical staff that guarantees results.

Key People:

  • Garcia Casado, Francisco Javier
  • Martínez De Juan, José Luís
  • Prats Boluda, Gema
  • Ye, Yiyao  

Responsable:

  • Garcia Casado, Francisco Javier 

Information about technology:

  • Applications Non-Invasive Monitoring of Gastrointestinal Activity
    Help to the Dignostics of Gastrointestinal Pathologies
    Studies of Biological Signals of Similar Characteristics / Problems
  • Benefits it provides Allows the study of gastrointestinal activity through a non-invasive technique that is not annoying for the patient.
    It is a technique easy to use by the clinical staff to which they are already accustomed (use of electrodes on body surface)
    It is a low cost technique compared to other techniques such as magnetic or based on biomedical images.
  • Technical advantages The developed technique allows a mapping of the gastrointestinal activity on the abdominal surface.
    You can carry out activity propagation studies.
    The necessary technical means are usual for the capture of other bioelectric signals.

Modeling and simulation of cardiac electrical activity

Cardiac arrhythmias are one of the main causes of morbidity and mortality in developed countries. Despite the intense research developed, the mechanisms of generation, maintenance and termination of these arrhythmias are not totally clear. In addition, its treatment is not entirely satisfactory. Although today a large amount of information is available at different levels: sub-cellular, cellular, tissue, organ and system, the prediction, prevention and treatment of cardiac arrhythmias remains one of the greatest scientific challenges .

A new and promising technology based on the integration of different levels of information in computer models allows research in this field. Within this line, researchers of the CI2B Universitat Politècnica de València work in the study of the causes of cardiac arrhythmias through modeling and simulation.

It has been  developed realistic three-dimensional models of the heart that include, with a high degree of detail, genetic characteristics of the ion currents, and their mutations, the electrophysiological characteristics of the different types of cardiac cells and the anatomical structure of the different cardiac tissues. of an anatomical model of the torso.

Using these models, we study situations that generate and perpetuate complex pathological rhythms and their relationship with electrical signals used in clinical diagnosis (ECG). These integrated multi-scale models are used to improve the prevention and diagnosis of cardiac pathologies, surgical procedures related to radiofrequency ablation and knowledge of the pro-arrhythmic effects of different antiarrhythmic drugs.

The research lines that this group has developed in the field of biomedical engineering has allowed it to collaborate with groups of both national and foreign. As a result of these collaborations, different research projects have arisen, funded both at local, state and European Union level.

Key People:

  • Cardona Urrego, Karen Eliana
  • Ferrero De Loma-Osorio, José María
  • Gomis-Tena Dolz, Julio
  • Romero Perez, Lucia
  • Romero Rojas, Mario Alfonso
  • Saiz Rodríguez, Francisco Javier
  • Trénor Gomis, Beatriz Ana  

Responsable:

  • Trénor Gomis, Beatriz Ana  

 


Information about technology:

  • Applications - Study of cardiac activity
  • Benefits that it contributes - Improvement of the prevention and diagnosis of cardiac pathologies
    - Improvement of surgical procedures related to radiofrequency ablation
    - More information on pro-arrhythmic effects of different antiarrhythmic drugs.
  • Technical advantages The developed three-dimensional models of the heart stand out for their high degree of detail

Tissue electrical stimulation systems

Sistemas que permiten la estimulación de tejidos a través de unos electrodos en contacto con los mismos. Sistemas de estimulación nervisosa, sensitiva y cortical. Sistemas de estimulación transtorácica.

Key People:

  • Gomis-Tena Dolz, Julio
  • Saiz Rodríguez, Francisco Javier  

Responsable:

  • Saiz Rodríguez, Francisco Javier  

Information about technology:

  • Applications Neurosurgery
    Navigators for surgery
  • Benefits that it contributes
  • Technical advantages

Patents and results

Apparatus and method for obtaining information on cerebral hemodynamics

The method comprises the steps of applying an excitation signal (Se) to the head, and capturing two output signals (S1) and a second output signal (S2), with different dependencies of volume or cerebral blood flow and volume and blood flow of the scalp. These signals are treated to obtain a result that reflects the cerebral blood flow, with minimal contamination by the blood flow of the scalp.

Scientific interlocutor:

  • Pérez Martínez, Juan José  

Inventors / authors:

  • Guijarro Estelles, Enrique Domingo
  • Pérez Martínez, Juan José  

Information on the exploitation potential:

  • Advantages versus alternative technologies The described method and device provides a qualitative and indirect measure of cerebral blood flow dynamics. The method is non-invasive and allows continuous monitoring, so it can provide information on the patient's condition in real time. In addition, its portable nature and low cost make it accessible to any health center, including mobile units.

Surgery Tool (Evotool)

The invention relates to a surgical instrument, in particular it is hand instruments for minimally invasive surgery (MIS). It is a tool with functions of grip, dissection, suture, cutting and cauterization during the operation. The novel ball-shaped design allows the surgeon postural freedom and provides important improvements in terms of ergonomics and precision during use.

Scientific interlocutor:

  • Conejero Rodilla, Andrés  

Inventors / authors:

  • Conejero Rodilla, Andrés
  • Dolz Lago, José Francisco 
  • Martínez De Juan, José Luís
  • Pace Bedetti, Horacio Martín  

Information on the exploitation potential:

  • Applications EVOTOOL is located within the area of ​​surgical material, specifically in hand instruments for minimally invasive surgery (MIS). The present invention is focused on the field of laparoscopy, for tools for grasping, dissecting, suturing and cutting, varying the thickness of the stylet can be extrapolated to any of the different endoscopic techniques where tools of this nature are required, and adding a Monopolar or bipolar electrical outlet can be used as HF technology (high frequency tools widely used to cauterize, suture or cut during operation
  • Advantages versus alternative technologies The advantages over conventional laparoscopic surgery tools

 

EVOTOOL allows POSTURAL FREEDOM to the surgeon during the operation. Postural freedom is the possibility of adopting free-form positions when the subject develops a task.
EVOTOOL does not have a scissor shape, which means that there are no rings where the fingers can be inserted or the possibility of damaging the phalanges with prolonged use.
EVOTOOL, unlike conventional tools, allows the subject to move the hand freely, relaxing the grip during the operation, even allowing the tool to be operated with one or two fingers, which facilitates relaxing the phalanges during the operation.
The precision axis of EVOTOOL is located in the center of a sphere located in laparoscopic practice in the palm of the hand, very close to the precision axis of the hand.

Methods for determining an identifier for use in methods for diagnosing haemophilic arthropathy, methods and apparatus for diagnosing

A methodology has been developed for the determination of a classifier and a classification threshold for its use in the diagnosis of hemophilic arthropathy (HA).

These methods include the analysis of the variations in the center of pressures of subjects who perform a series of tests on a balance platform such as: standing eyes open, standing closed eyes, monopedestación on dominant leg, and non-dominant leg.

The inventors have found that from the movements of the pressure center, especially in unilateral positions, the information that can be derived allows a reliable diagnosis of HA. In addition, particularly the size and shape of the area covered by the pressure center, the velocity and power spectral density of the pressure center during these tests are indicative of the presence or absence of HA. Different parameters indicative of these concepts can be used.

By comparing the parameters of the subjects known to suffer from HA with the same parameters for the subjects it is known that they do not suffer from it, a classifier (and the corresponding classification threshold) can be determined through learning processes automatic. The inventors have found that a classifier and a classification threshold according to this method can be used to make a reliable diagnosis for individual patients in a quick and easy procedure. A patient will only have to perform simple short tests using a pressure platform and then in an automated way a diagnosis can be made.

The inventors found that using methods as described above it was possible to derive classifiers and classification thresholds that have a reliability of more than 90% when used for the diagnosis of HA.

Scientific interlocutor:

  • Prats Boluda, Gema  

Inventors / authors:

  • Garcia Casado, Francisco Javier
  • García Massó, Xavier
  • González Moreno, Luis-Millán
  • Querol Fuentes, Felipe 
  • Ye, Yiyao  

Information on the exploitation potential:

  • Applications Rapid, simple and safe diagnosis of the presence of arthropathic alterations in the load joints of the hemophiliac patient with the consequent possibility of early initiation of adequate therapy.
    Presumably, it would initially be used in the hemophiliac patient's medical care units. Its extension to Health Centers would represent the provision of a simple and effective tool for screening alterations in the muculoskeletal system of loading and referral to medical specialties. In summary, an early diagnosis of musculoskeletal injuries.
  • Advantages versus alternative technologies Regarding the application of the methodology described for the diagnosis of AH, the alternative technologies would be the physical explorations and the use of medical images. Medical images require qualified personnel and expensive equipment. A disadvantage of the medical image for the patient is that they are exposed to several doses of X-rays. On the other hand, the physical examination also requires qualified personnel and can be time consuming for patients. In addition, early diagnosis of HA with these known techniques can still be relatively complicated. Thus, the main advantages associated with the technique object of invention its main advantages would be the simplicity and diagnostic objectivity; and with it the possible early application of specific therapy that would represent a slowing down of the degenerative process and an increase in the quality of life of the hemophiliac patient.

System for high performance recording of bioelectric signals based on flexible ring sensors

The present invention is a system based on flexible annular sensors for obtaining non-invasive records of high performance of bioelectric signals on body surface. The system is composed of a flexible capture stage formed by ring and disk electrodes and by a stage in which the captured signals are processed. The quality of the signal is obtained from the annular configuration of the electrodes, the flexibility of the substrate in which its manufacture is proposed, which allows a greater adaptability to the body contour. In addition, the sensors of the designed system have multiple outputs, being configurable the weight of each of the voltages captured by the conductors in each of the outputs. This implies being able to obtain, with a single sensor, different output signals corresponding to different spatial distributions of sensitivity and by means of the weights assigned to each one to configure the desired output. The system also allows the possibility of mapping surface bioelectric signals by using several absorption sensors embedded in a flexible and adhesive matrix.

Scientific interlocutor:

  • Prats Boluda, Gema  

Inventors / authors:

  • García Breijo, Eduardo
  • Garcia Casado, Francisco Javier   
  • Ibañez Civera, Javier 
  • Martínez De Juan, José Luís   
  • Prats Boluda, Gema   
  • Ye, Yiyao  

  • Applications The invention allows obtaining non-invasive records of bioelectric signals with high sensitivity, ease of clinical use and comfort for the patient.
    One of the applications is the recording of the electrocardiographic ECG signal both in resting conditions for diagnosis of cardiac pathologies (traditional electrocardiography) and in long-term ambulatory records (holter) as well as in stress tests.
    Another application is the non-invasive recording of the uterine myoelectric signal during pregnancy and delivery (electrohysterogram, EHG). Currently, the clinical application of this technique for the study of uterine dynamics is limited because conventional techniques of signal capture do not have sufficient quality. With this new technology, relevant data could be obtained, for example, for the diagnosis of preterm birth.
    The system can also be applied for the monitoring of intestinal myoelectric activity, called electroenterogram (EGn). This signal is also very weak compared to that of the heart and that of breathing; a record of its quality allows a rapid, non-invasive and low-cost diagnosis in the face of pathologies that present a high mortality rate due to the long diagnosis time.
    Other possible uses would be the recording of the electromyogram (EMG), the electrogastrographic signal, the diaphragmatic signal, as well as the encephalographic signals, the oculogram or the retinogram.
  • Advantages versus alternative technologies - Greater sensitivity and spatial resolution in the location of bioelectric signals with respect to conventional electrodes.
    - The annular and disc electrodes are developed on flexible substrates that adapt perfectly to the body contour, which offers a better quality of the recorded signal
    - The sensors have multiple outputs to which different weights can be assigned, allowing to select with a single sensor the area of ​​the body from which it is desired to record the bioelectric signals.
    - It is possible to pick up weak signals that until now it was not possible to record with sufficient quality.
    - The sensor developed is modular, so that the electrodes can be replaced by new ones.
    - The system allows the possibility of mapping bioelectric signals on the surface by using several absorption sensors embedded in a flexible and adhesive matrix.
  • System for the characterization of quartz crystal resonant sensors in fluid media, calibration and compensation procedure of quartz crystal capacity

    The system of the invention continuously and automatically supplies the series resonance frequency and the resistance of the dynamic branch and of a quartz resonator. The frequency supplied is independent of the dynamic resistance and the static capacity of the crystal. The system is designed to compensate the capacitive effects in parallel with the sensor, incorporating a phase-locked loop and a circuit that provides the dynamic resistance of the resonator. It also includes procedures for calibration of the circuit external to the sensor and for capacitive compensation. . The invention has utility in applications in which quartz resonators are used as sensors, such as: for the determination of the visco-elastic properties of fluids, for the detection of specific chemical species in gaseous environment or in solution by means of the suitable coating of the sensor , among other.

    Scientific interlocutor:

    • Arnau Vives, Antonio  

    Inventors / authors:

    • Arnau Vives, Antonio
    • Jiménez Jiménez, Yolanda
    • Sogorb Devesa, Tomás Carlos  

    Information on the exploitation potential:

    • Advantages versus alternative technologies * Alternative Products
      Q-SENSE: Europe
      MAXTEK
      ECO-CHEMIN
      * Advantage
      Accuracy in the characterization of the system / process

    Measurement system and method of piezoelectric resonators for nano-gravimetry applications in fluid media

    The invention provides a method, an electronic characterization system and a support and measuring cell for monitoring a chemical or physical process whose result can be evaluated in terms of transfer, accumulation or loss of mass on a coating deposited on a piezoelectric sensor, and faced to a fluid medium whose physical characteristics remain stable. The invention takes advantage of the derivation of an analytical expression that establishes a simple relationship between the phase variation of a fixed frequency signal, which interrogates the piezoelectric resonator, and the variation in the mass density of the coating. The invention has utility in applications in which piezoelectric resonators are used for the characterization of biochemical and electrochemical processes such as: piezoelectric biosensors and immunosensors, characterization of processes and materials by ac electrogravimetry, detection of chemical or biological substances in solution, among others.

    Scientific interlocutor:

    • Arnau Vives, Antonio  

    Inventors / authors:

    • Arnau Vives, Antonio
    • García Mollá, Pablo
    • Garcia Narbon, Jose Vicente
    • Jiménez Jiménez, Yolanda
    • Montagut Ferizzola, Yeison
    • Reig Fabado, Antonio  

    Information on the exploitation potential:

    • Applications Detection of chemical or biochemical components in solution, biosensors, immunosensors, detection of pathogens, antigens and other chemical components; characterization of superficial processes and processes that can take place at molecular or atomic level on thin layers.
    • Advantages versus alternative technologies Integration, ease of use and sensitivity.

    Portable device for the conditioning, recording and wireless transmission of bioelectric signals: maternal-fetal monitoring application (ART-MMF)

    A device for the conditioning, digitalization, recording and wireless transmission (Bluetooth) of bioelectric signals has been developed.

    The developed device is small, light and portable, so it is susceptible to be used in a wide variety of applications of monitoring and recording of body signals. In the specific case of implementation, its use is intended for maternal-fetal monitoring, which may include cardiac information, both maternal and fetal, as well as information on the activity of the uterine muscle and its electrophysiological state.

    Scientific interlocutor:

    • Garcia Casado, Francisco Javier  

    Inventors / authors:

    • Alberola Rubio, José 
    • Garcia Casado, Francisco Javier
    • Perales Marín, Alfredo
    • Prats Boluda, Gema
    • Ye, Yiyao  

    Information on the exploitation potential:

    • Applications The developed device is small, light and portable, so it is susceptible to be used in a wide variety of applications of monitoring and recording of body signals. In the specific case of implementation, its use is intended for maternal-fetal monitoring, which may include cardiac information, both maternal and fetal, as well as information on the activity of the uterine muscle and its electrophysiological status. All this with potential to be used to assess maternal-fetal well-being, monitoring of uterine dynamics, estimation of intrauterine pressure, prediction of premature birth, assessing the response to different types of drugs, estimating the time horizon of delivery, need for its induction, the success of it, the possible parking of labor, etc.
    • Advantages versus alternative technologies For its possible application as a non-invasive monitor of uterine dynamics, compared to conventional tocography (measurement of pressure on the abdominal surface), it has the advantage of a better ability to detect contractions, not need tight belts, and present better response in obese patients.
      As regards other systems for the conditioning and transmission of bioelectric signals, there are countless systems in the market for this purpose, some of which are similar or even superior in certain aspects to the developed one. The main advantage of the present device is its specific suitability for the registration of even the weakest components of the signals on the surface of pregnant women.

    ELISA Kits for the analysis of plaguicides in food and in the environment

    Kits de ELISA (inmunoensayo enzimático en placa) para la detección y cuantificación rápida,
    ELISA kit (enzymatic immunoessay in plate)for a quick, sensitive and specific quantification of plaguicide waste in food and environment (fruits and vegetables, water, ground). The essays use as primary reactive monoclonal antibodies obtained in the own laboratory, with a hich specificity and afinity for each plaguicide. The antibodies react selectively with the substances to analyze, and an enzymatic mark gives a colour signal proportional to the quantity of each plaguicide. There are 11 ELISA individual kits and 5 multianalyte ELISA kits for different plaguicide families: fungicide (thiabendazole) and insecticide: Organoclorated (DDT, endosulfan, etc.), Organofosforated (azinphos, chlorpyrifos, TCP) y N-metil-carbamate (carbaryl, carbofuran, methiocarb, etc.).

    Inventors / authors:

    • Montoya Baides, Ángel  

    Information on the exploitation potential:

    • Applications Agri-food industry and the environment
    • Advantages compared to alternative technologies * Chromatograph
      The most frequently used instrument for the detection of contaminating substances in substances is the chromatograph.
      CHROMATOGRAPHER: Apparatus used to perform chemical analysis methods for the separation of the components of a mixture by distribution between two phases, a stationary and a moving one, which was initially used to separate colored substances.

    The advantages offered by the ELISA kit versus the chromatograph are the following:
    - Lower cost
    - Adaptation to the particular user
    - Rapidity in diagnosis
    - Ease of handling

    - Reduction of economic costs
    - Adaptation to the particular user
    - Quick improvement processes
    - Ease of handling

    Smart Reader of Blister

    Card holder / reader / tutor / blister aid printed with electronic circuit for detection of compressed compartment or capsule rupture; of repeated and continuous use, multiblister. With internal memory and warning functions, alarms and control of medication takes.

    Scientific interlocutor:

    • Rodríguez Gil, Rafael  

    Inventors / authors:

    • Rodríguez Gil, Rafael
    • Saiz Rodríguez, Francisco Javier  

    Information on the exploitation potential:

    • Applications management of the blister of drugs for the control, monitoring and tutoring of the extraction and taking of medication, to increase the therapeutic compliance and the adherence to it.
    • Advantages vs. alternative technologies Do not greatly alter the manufacture of medication blisters, reducing costs and facilitating application to multiple medications.
      Simplicity in its use and intuitive.

    3D computational model of realistic human atrium and torso for the simulation of atrial arrhythmias

    Modelo computacional 3D de aurícula y de torso humanos realistas para la simulación de arritmias auriculares

    Scientific interlocutor:

    • Saiz Rodríguez, Francisco Javier  

    Inventors / authors:

    • Ferrer Albero, Ana 
    • Saiz Rodríguez, Francisco Javier  

    Information on the exploitation potential:

    • Applications
    • Advantages versus alternative technologies

    A hierarchical and autonomous system for the control and monitoring of patients in cardiac rehabilitation

    It performs personalized control and surveillance of a plurality of users who perform physical exercise simultaneously (cardiac rehabilitation or any other). It comprises an elastic band in the thorax of each user and with a plurality of electrodes and a wireless user unit for capturing the electrocardiographic signals, which it sends to a wireless portable unit, and this unit to a central wireless control unit that stores the data cardiology of the users as well as the different exercises that each one can perform based on these data and the received electrocardiographic signals, to program the wireless portable unit that establishes alarms corresponding to the limits of the cardiological parameters of the user and to govern the functioning of the gymnastics device based on cardiological data, electrocardiographic signals and generated alarms.

    Scientific interlocutor:

    • Saiz Rodríguez, Francisco Javier  

    Inventors / authors:

    • Ferrero De Loma-Osorio, José María
    • Giménez Cisilino, Gabriel
    • Gomis-Tena Dolz, Julio
    • Guixeres Provinciale, Jaime
    • Rodríguez Gil, Rafael
    • Saiz Rodríguez, Francisco Javier
    • Salvador Sanz, Antonio  

    Information on the exploitation potential:

    • Applications
    • Advantages versus alternative technologies